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tetracycline induceable lentiviral vector ( oct4 , sox2 , klf4 , c myc , lin28 )  (Coriell Institute for Medical Research)
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Coriell Institute for Medical Research tetracycline induceable lentiviral vector ( oct4 , sox2 , klf4 , c myc , lin28 )
Summary of the literature on findings in reprogrammed neuron‐like cells derived from patients with schizophrenia and schizoaffective disorder
Tetracycline Induceable Lentiviral Vector ( Oct4 , Sox2 , Klf4 , C Myc , Lin28 ), supplied by Coriell Institute for Medical Research, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
tetracycline induceable lentiviral vector ( oct4 , sox2 , klf4 , c myc , lin28 ) - by Bioz Stars, 2026-03
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Summary of the literature on findings in reprogrammed neuron‐like cells derived from patients with schizophrenia and schizoaffective disorder

Journal: The European Journal of Neuroscience

Article Title: Are reprogrammed cells a useful tool for studying dopamine dysfunction in psychotic disorders? A review of the current evidence

doi: 10.1111/ejn.13418

Figure Lengend Snippet: Summary of the literature on findings in reprogrammed neuron‐like cells derived from patients with schizophrenia and schizoaffective disorder

Article Snippet: Brennand et al . ( ) , Fibroblasts → iPSCs Tetracycline induceable Lentiviral vector ( OCT4 , SOX2 , KLF4 , c‐MYC , LIN28 ) → NPCs → iNeurons , Four cases with three SCZ 1 SZA Two patients are siblings Coriell Cell Repository GM02038 GM01792 GM01835 GM02497 Six healthy subjects Coriell Cell Repository GM03440 GM03651 GM04506 American Type Culture Collection AG09319 AG09329 One neonatal foreskin CRL‐2522 , Forebrain NPCs and early neurons , NPC and early neuron gene expression resembles first trimester forebrain neurons. SCZ and healthy subjects display similar gene expression and spatial and temporal identity. NCAM1 , NLG1 , NRXN1 and NRXN3 ↓ in SCZ 481 genes expressed at > 1.3 fold difference between SCZ and healthy subjects in NPCs; differences are conserved in older stages. Aberrant cell migration in SCZ cells (no effect of loxapine or clozapine) Morphological difference in mitochondria Increased oxidative stress in SCZ.

Techniques: Derivative Assay, Plasmid Preparation, Mutagenesis, Expressing, Inhibition, Staining, Transmission Assay, Clone Assay, Over Expression, Binding Assay, Migration, Infection, shRNA, Genome Wide

Summary of the literature on findings in reprogrammed neuron‐like cells derived from patients with bipolar disorder

Journal: The European Journal of Neuroscience

Article Title: Are reprogrammed cells a useful tool for studying dopamine dysfunction in psychotic disorders? A review of the current evidence

doi: 10.1111/ejn.13418

Figure Lengend Snippet: Summary of the literature on findings in reprogrammed neuron‐like cells derived from patients with bipolar disorder

Article Snippet: Brennand et al . ( ) , Fibroblasts → iPSCs Tetracycline induceable Lentiviral vector ( OCT4 , SOX2 , KLF4 , c‐MYC , LIN28 ) → NPCs → iNeurons , Four cases with three SCZ 1 SZA Two patients are siblings Coriell Cell Repository GM02038 GM01792 GM01835 GM02497 Six healthy subjects Coriell Cell Repository GM03440 GM03651 GM04506 American Type Culture Collection AG09319 AG09329 One neonatal foreskin CRL‐2522 , Forebrain NPCs and early neurons , NPC and early neuron gene expression resembles first trimester forebrain neurons. SCZ and healthy subjects display similar gene expression and spatial and temporal identity. NCAM1 , NLG1 , NRXN1 and NRXN3 ↓ in SCZ 481 genes expressed at > 1.3 fold difference between SCZ and healthy subjects in NPCs; differences are conserved in older stages. Aberrant cell migration in SCZ cells (no effect of loxapine or clozapine) Morphological difference in mitochondria Increased oxidative stress in SCZ.

Techniques: Derivative Assay, Plasmid Preparation, Expressing, Generated, BrdU Staining